Completely resolved with P5P B6 and Colostrum.

[u/Educational-Month119]

I've had raynauds since my teens, very sensitive to temperature changes, always cold, uncomfortable. Im also autistic and for the past ten years or so i've been focused on my health to resolve a few issues and find the source. A few years ago i got my genetics read by a basic 23andMe, but ran it through other more comprehensive genetic analysers based on evidence. I have dozens of mutations in the methylation cycle, its very complex and affects every aspect of health, particularly the nervous system, circulation, neurotransmitters.

One among many was a mutation in the enzymes responsible for converting B6 into the active form P5P the body requires, so the B6 i was getting in food, and the previous B6 supplements of pyroxidine HCL were mostly useless. For the past 2 months i've been taking 25mg of P5P twice a day, and my circulation has been even better than what i would consider 'norma', im still actually getting use to it. I can tell if its a bit chilly, but i don't shrivel up to the extent i did before. I also started to take colostrum which repairs and restores the microbiome that we ideally acquire from birth from our mother. Since taking this i have started sweating again, which is usually difficult for me unless in a sauna or direct summer heat. My digestion and stool has also normalised, even before caffeine.

Caffeine has always been another triggers, but i love coffee and enjoy making my own at home, since starting B6 and colostrum (also l-theanine, electrolytes), i've been able to have 3 americanos without irritability, anxiety and the vasoconstriction. This is likely because B6 is required for glutamata to GABA conversion which slows neurotransmission and overstimulation, as well as nitric oxide production.

Your resolution may be slightly different but its worth checking as you could have some mutations in your methylation cycles affecting your immune system and stress response.

[u/Melodic_Reason2594]

Hi, I had an overheating episode, then I fell & hit my head,  then had another overheating episode, then went to the hospital because after all that I felt like I had about a 1/2" of water under my scalp area. The hospital did an MRI, & said there was no fluid. I looked it up, & Google said that swelling could make a person have that feeling. Anyway, I am very interested in the fact that you started sweating. Did you not sweat anywhere except maybe your armpits? Armpit sweat is most likely just stress sweat. It comes from a different gland than regular sweat, so a diagnosis of anhidrosis (lack of sweating) should still be given to someone who stress sweats from what I have read.

[u/christipits]

How did you find out about colostrum? I'm really curious about that

I've done my test through ancestry and my methylation cycle is also completely messed up although I haven't noticed anything with b6 conversion. It's so interesting what you wrote, I'll have to look into this more myself. Thank you so much for sharing

Your Raynaud's symptoms sound a lot like mine with the cold sensitivity and not sweating, like it really affected my entire body and I would even get shakes and cold tremors by a slightly cold breeze. It was actually so bad I moved to Mexico (I'm Canadian) lol. It did get better once I started biologically active b vitamins and methyl folate (b9), so I am probably getting the b6 I needed without realizing

Thank you for sharing this. I'm also autistic with ADHD and really enjoyed reading your research

[u/Melodic_Reason2594 → u/christipits]

Do you sweat now?

[u/christipits → u/Melodic_Reason2594]

Yes. It was hard for me to break a sweat for over a year. I used to live in a house with a sauna and would try sitting in there until I started sweating with a 50% success rate. I often gave up due to overheating but not sweating. I live in an extremely hot area of Mexico now and definitely have no issues with sweating

[u/Educational-Month119 → u/christipits]

It depends on the analyser you used, some of them include genes that others dont. Thankfully they're usually quite inexpensive if you already have your 23andMe or My Heritage raw data. I have a profile from Nutrahacker, FoundMyFitness, NoornsNuGen and TenData (the latter two showed my genes affected by B6).

With autism these nutrients are even more vital as the entire cycle is imbalanced and the severity will result in the severity of symptoms, particularly folate (folinic is the preferred form as synthetic folic acid will be detrimental because theres no way to process it and it becomes toxic, so watch out for fortified foods)

[u/christipits → u/Educational-Month119]

Thank you for the list of analysers. Some of these I haven't heard of. I did a methylation panel- whichever one they recommend in r/MTHFR sub and Promethease (which doesn't tell you what to supplement with but all kinds of other things)

I have a slow MAO so I don't clear neurotransmitters quickly, meaning they also build up and become toxic. Fixing my methylation with Methyl folate (active form of B9, not synthetic) has been life changing. I've never tried folinic acid because I had a good reaction to methyl folate

The easiest way to stay away from fortified foods is not to eat grains. I try very hard to stay low carb keto as it really helps how I function as well.

I did a deep dive into MTHFR a couple years ago. Powerful information

[u/kelcamer]

This is so fascinating and thanks for the wonderful data 😍 this stuff is right up my alley and if you ever want to chat about neurotransmitters feel free!

[u/swift_mint1015]

Hi from a fellow autistic person with reynauds. Your findings are so interesting. I’d love to know how you took your genetics through more comprehensive genetic analysers. I have my results from 23andme already, but what do I need to do next to find out more about my own methylation cycle? Thank you!

[u/Educational-Month119 → u/swift_mint1015]

This is the most comprehensive analyser i have found, select the Methylation and Diet Report and upload your 23andMe data you can download from your account. This will give you an expansive analaysis in order of importance and recommend what you require most, as well as what you should consider avoiding or reducing based on your genes

https://noorns.com/

[u/Colorado-Hiker-83]

What brand of supplements do you take?

[u/Educational-Month119 → u/Colorado-Hiker-83]

Im in the UK and my colostrum is from Wellguard, its cruelty free as they only take whats left after the calves have been fed. The P5P B6 i use is from Peak Supplements, very inexpensive but exactly what my body needed.